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Phagebiotics for a Healthy Life

... examples of such preparations are “Pyo-bacteriophage” produced by the Eliava Institute of Bacteriophages, Microbiology and Virology in Tbilisi, Georgia, and “Complex pyobacteriophage” produced by NPO Microgen . In the same context, the first phage therapy trial for human wound infections in the USA utilized a multivalent phage preparation containing eight different phages lytic for three bacterial pathogens commonly found in infected wounds: Escherichia coli , Staphylococcus aureus , and ...

Modified: 11.04.2017
bacteriophages , phage therapy , probiotics , phagebiotic , phage-based preparations , phage biocontrol , bacteriophage
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Phages Attack # A History of Bacteriophage Production and Therapeutic Use in Russia

... complications in wounds through the use of bacteriophages, which were not only completely harmless but also widely available, inexpensive and easy-to-manufacture therapeutic agents. Bacteriophages in the Battle of Stalingrad The further history of phage therapy is associated with the tragic events of World War II in 1941–1945. In those years, with a total lack of antibacterial drugs (at the beginning of the war, the Soviet Union did not have a technology to produce penicillin), it was decided ...

Modified: 15.03.2017
phage therapy , choleraic bacteriophage , treat for injuries , battle of Stalingrad , Research and Production Association ‘‘Microgen’’ , bacteriophages , bacteriophage
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Bacteriophages: 100 years in the service of mankind

... (Sanger et al. , 1977). The sequencing was performed by the group of the English biochemist F. Sanger, the author of the DNA sequencing method of the same name Genetic modifications serve to change the phage specificity and increase the efficacy of phage therapy. To achieve this, the most aggressive phages are fitted with recognition structures binding them with the target bacteria. In addition, virus genomes are imbedded with genes coding the proteins toxic for bacteria, which disrupt metabolism – ...

Modified: 15.03.2017
bacteriophage , phage therapy , enzymes , phage display , nano materials , bacteriophages
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Truth about Phage Therapy or a Memo to Physicians and Patients

... applied in medicine, our knowledge about the diversity of these viruses, about mechanisms of their interaction with bacteria, and about competition with their cognates is still insufficient to use their full therapeutic potential. Safe and Efficient Phage therapy emerged almost immediately after bacteriophages were discovered; however, expanded trials of these antibacterial tools were launched in the Soviet Union only in the late 1930s. The trials proved the efficiency of bacteriophages as preventive ...

Modified: 15.03.2017
bacteriophages , phage therapy , phage-based preparation , bacteriophage
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Phages in Your Garden # Problems and prospects of bacteriophage applications in horticulture

... Phages are natural inhabitants of the same ecological niches as bacteria; hence, their use does not affect the state of major ecological systems. Phage breeding technologies and applications are logical, relatively simple and inexpensive. Agricultural phage therapy can be combined with most other chemical and biological control methods and is safe both for the treated plants and for humans and animals. However, it should be understood that phage phytocontrol is not a panacea against plant pathogens....

Modified: 15.03.2017
diseases of agricultural plant , bacteriophage , phage therapy , protein engineering , enzymology , molecular diagnostics , bacteriophages
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Bacteriophages – the enemies of our enemies

... these tiny viruses When these bacteria killers were discovered a hundred years ago, they immediately took center stage: enthusiasts believed that the miraculous viruses would completely rid mankind of infectious diseases. The new method – ​ phage therapy  – ​became widely known after the publication, in 1925, of Arrowsmith , a famous novel by Sinclair Lewis, which told an idealized story of a young microbiologist who had discovered a wonder drug. The book earned the author the Nobel ...

Modified: 14.03.2017
bacteriophage , bacteriophages , phage therapy , bacteria viruses , biosphere , synthetic biology
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Bacteriophages: The Enemies of Our Enemies

... be fortunate for humans, since bacterial receptors are the virulence factors that determine survival and reproduction of a pathogen in the host body. Moreover, bacterial mutants resistant to phages are usually less pathogenic than their progenitors. Phage therapy: per aspera Discovery of viruses that kill bacteria gave rise to a new method for the control of bacteria. The most evident application is phage therapy, i.e. the use of bacteriophages for treating human bacterial infections. An advantage ...

Modified: 30.08.2014
bacteriophage , lytic phage , bacteria , infection , phage therapy
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Bacteriophages: The Enemies of Our Enemies

... be fortunate for humans, since bacterial receptors are the virulence factors that determine survival and reproduction of a pathogen in the host body. Moreover, bacterial mutants resistant to phages are usually less pathogenic than their progenitors. Phage therapy: per aspera Discovery of viruses that kill bacteria gave rise to a new method for the control of bacteria. The most evident application is phage therapy, i.e. the use of bacteriophages for treating human bacterial infections. An advantage ...

Modified: 14.12.2013
bacteriophage , lytic phage , bacteria , infection , phage therapy
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