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A Toxicological Crime Story # The Case of Balkan Endemic Nephropathy

Are you not afraid to live in this world yet? In the world where any breath, any ingested piece may turn out to be deadly? Shockingly, plenty of things around us are quite noxious and, combined with a genetic predisposition, can cause gravest health implications. A compelling evidence for this statement is a thrilling and puzzling story, narrated by its direct participants, of the years-long search for a killer toxin causing most severe kidney failure in Serbian peasants and Belgian society women...

Modified: 14.04.2015
plant toxins , Balkan endemic nephropathy , mutagenesis , carcinogenesis , DNA repair
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NMR Method: Towards Sensitive Detection

... moreover, cell metabolism creates reactive oxygen species. All this primarily affects the genomic DNA by damaging it and provoking cancers and various cardiovascular, neurodegenerative, and autoimmune diseases. Cells protect genetic information by means of DNA repair systems. The Novosibirsk researchers used NMR spectroscopy to investigate DNA structures with different defects and DNA complexes with repair enzymes. Traditionally, these studies are carried out using X-ray spectroscopy of DNA and protein–nucleic ...

Modified: 14.04.2015
nuclear magnetic resonance , magnetic resonance imaging , spin hyper-polarization , para-hydrogen , polarization transfer , DNA repair , cataract
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Padlocked DNA

... may bring to naught the treatment efforts. Siberian researchers have developed a new method for detecting the Ku antigen, a key protein of the system that repairs the DNA double-strand breaks caused by tumor radiotherapy. That is why such studies of DNA repair mechanisms are highly important for practical use as well as basic research DNA is one of the treasures of a living cell, which provides for its regular functioning. The constantly emerging lesions in DNA molecules are “fixed” by specialized ...

Modified: 30.12.2014
Ku antigen , DNA repair , double-strand break , AP site , protein–DNA cross-linking
Path: Главная / Articles
Padlocked DNA

... may bring to naught the treatment efforts. Siberian researchers have developed a new method for detecting the Ku antigen, a key protein of the system that repairs the DNA double-strand breaks caused by tumor radiotherapy. That is why such studies of DNA repair mechanisms are highly important for practical use as well as basic research DNA is one of the treasures of a living cell, which provides for its regular functioning. The constantly emerging lesions in DNA molecules are “fixed” by specialized ...

Modified: 30.08.2014
Ku antigen , DNA repair , double-strand break , AP site , protein–DNA cross-linking
Path: Главная / Articles
The Cell: From Maturity to Childhood

... ability there are enzymes that actively maintain methylation. But does this mean that methylation is irreversible? The answer is no. Two methods used by cells for an active demethylation were simultaneously discovered in 2009; both of them utilize the DNA repair system *, restoring the nucleic acid that was purposefully damaged by the cell itself! Researchers from the Group of Biopolymer Interactions at the Institute of Chemical Biology and Fundamental Medicine in Novosibirsk, in collaboration with ...

Modified: 18.12.2012
stem cells , pluripotency , reprogramming , epigenetics , DNA repair
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Sentinels of Genome

... that ultraviolet damaged the cell’s genetic material, whereas the results in question suggested that visible light enhanced the restoration of genetic material. This process was named photoreactivation . This was how, very casually and by chance, DNA repair was discovered – and this process is not less important than the other major molecular genetic processes of replication, transcription, and translation of genetic material. The story of the princes of Serendip took place once again… What’s ...

Modified: 30.12.2009
DNA repair , Mutagenesis , DNA damage , genotoxic stress , heritable diseases
Path: Главная / Articles

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