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The Postgenomic Era, or Why We Need 300,000 Mice Strains

... depending on whether the gene expression was inhibited by removal (off) or addition (on) of the antibiotic. The genetically engineered system with a Tet-off or Tet-on switch regulating expression of the gene encoding the green fluorescence protein (GFP), also inserted into the mouse genome, illustrates the work of such constructs. The transgenic embryos carrying such constructs and transplanted at an early developmental stage to wild-type females can change their coloration depending on the influx ...

Modified: 30.08.2008
genotype , genetically engineered mice , transgenic mice , knockout genes , knockout mice , gene expression , GFP , point mutations , genetic lines , embryo , cryobank , cryoarchive , SPF-animals , SPF-vivarium , Institute of Cytology and Genetics SB RAS
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