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Phagebiotics for a Healthy Life

... targeted impact on microflora can help fine-tune the microbiome and, as a result, may help prevent both infections and non-infectious diseases, ranging from diarrheal diseases to certain forms of cancer. With the modern advances in phage biotechnology, bacteriophages are becoming an attractive platform technology based on which various commercial products can be developed for numerous applications, ranging from preventing and/or treating people and animals to improving the safety of our foods Although ...

Modified: 11.04.2017
bacteriophages , phage therapy , probiotics , phagebiotic , phage-based preparations , phage biocontrol , bacteriophage
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Viruses and Bacteria: The Great Confrontation

... plants, fungi, and bacteria, is based on research about CRISPR-Cas bacterial systems. Originally, they were thought to participate in DNA repair, but in 2007 scientists found out the real purpose of these systems: they combat bacterial viruses, i. e., bacteriophages. It took scientists as little as nine years to make a giant leap from understanding the mechanism of bacterial immunity to human genome editing, and now they are making the first experiments on editing the DNA of human embryos. Moreover,...

Modified: 06.04.2017
bacteriophages , bacterial defense mechanisms , CRISPR-Cas systems , genome editing , bacteriophage
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Phages Attack # A History of Bacteriophage Production and Therapeutic Use in Russia

In Russia, bacteriophages have been produced and used for medical purposes for almost 80 years: during World War II, phages saved lives of thousands of wounded soldiers and prevented a cholera epidemic in the besieged Stalingrad before the famous Battle of Stalingrad....

Modified: 15.03.2017
phage therapy , choleraic bacteriophage , treat for injuries , battle of Stalingrad , Research and Production Association ‘‘Microgen’’ , bacteriophages , bacteriophage
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Bacteriophage, We See You!

A century has elapsed since Frederick William Twort, a British microbiologist, noticed transparent glass-like spots formed of dead bacterial cells in colonies of micrococci. For a long time after their discovery, the research into bacteriophages was of a phenomenological character because of the lack of adequate experimental tools. The scientists had no possibility for studying in detail the specific features of an antibacterial impact caused by bacteriophages since they are invisible ...

Modified: 15.03.2017
bacteriophages , bacteria viruses , morphology , electron microscopy , bacteriophage
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Bacteriophages: 100 years in the service of mankind

... molecular basis of living systems functioning. A crucial role in the successful research that resulted in determining the chemical nature of genetic molecules, breaking the genetic code and creating the gene manipulation technologies was played by the bacteriophages discovered at the beginning of the last century. Today, these bacterial viruses have learnt many jobs useful for people: they can be used not only as safe anti-infective drugs but also as disinfectants and even as basic elements of electronic ...

Modified: 15.03.2017
bacteriophage , phage therapy , enzymes , phage display , nano materials , bacteriophages
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Truth about Phage Therapy or a Memo to Physicians and Patients

The first clinical experiments with bacteriophages began a century ago. It seemed that the new method was bound to be a success: the approach looked faultless from a scientific standpoint and the results of its application were most promising. Then why did the interest in the therapeutic ...

Modified: 15.03.2017
bacteriophages , phage therapy , phage-based preparation , bacteriophage
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Phages in Your Garden # Problems and prospects of bacteriophage applications in horticulture

... We define biological control as the use of living organisms, i. e., specific predators or parasites, to suppress pest populations in agricultural areas. In particular, an appealing strategy to combat bacterial infections in plants is the use of bacteriophages , or bacterial viruses targeting specific pathogens. This concept has many advantages. Phages are natural inhabitants of the same ecological niches as bacteria; hence, their use does not affect the state of major ecological systems. Phage ...

Modified: 15.03.2017
diseases of agricultural plant , bacteriophage , phage therapy , protein engineering , enzymology , molecular diagnostics , bacteriophages
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A Nanoversion of Dr. Doolittle. Bacteriophages as an Alternative to Antibiotics in Veterinary

... superbacteriophage that can attack a large number of different microbial species and strains. Thus, it is more practical to use complex bacteriophage cocktails. Today, it is already technically and economically feasible to search for the necessary bacteriophages for an individual farm and to produce the corresponding biological preparations. This does not exterminate the overall range of pathogenic bacteria but makes it possible to select and use efficient bacteriophages against the bacteria most ...

Modified: 15.03.2017
salmonella , chicken , bacteriophages , antibiotics , efflux , drug resistence , infectious safety , bacteriophage
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Bacteriophages – the enemies of our enemies

What is a bacteriophage? Most will say this is a drug doctors told them about. Some will reply that bacteriophages (or just phages) are tiny viruses invading bacteria, and biologists will tell a good many amazing stories about their discovery, the important role they have played in the development of science and the promise held by up-to-date technologies ...

Modified: 14.03.2017
bacteriophage , bacteriophages , phage therapy , bacteria viruses , biosphere , synthetic biology
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Under the Sign of Bacteriophage: Paris – Tbilisi

Many pages in the history of science read like a fascinating novel, and this is exactly the case with the discovery of bacteriophages, or viruses that infect bacteria. The two most significant figures in the history of this discovery—a brilliant self-educated Frenchman, known as Félix d’Hérelle, and a Soviet microbiologist George Eliava, who was part of a well-known ...

Modified: 14.03.2017
bacteriophage , bacteriophages , d’Hérelle , Eliava , Georgian Institute of Bacteriophages , Institut Pasteur
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