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The Postgenomic Era, or Why We Need 300,000 Mice Strains

... with dozens of genotypes, this approach is still adequate; however, when there are thousands and hundreds of thousands of strains, the maintenance of mouse resources as breeding stocks becomes impossible. The way out of the dead-end is organization of cryoarchives. Collections of genetic animal strains can be currently preserved as frozen embryos, spermatozoids, ova, and even ovarian tissue. However, the leading archives of genotypes focus on embryos. The embryo is a diploid organism, whereas spermatozoids ...

Modified: 30.08.2008
genotype , genetically engineered mice , transgenic mice , knockout genes , knockout mice , gene expression , GFP , point mutations , genetic lines , embryo , cryobank , cryoarchive , SPF-animals , SPF-vivarium , Institute of Cytology and Genetics SB RAS
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