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The Postgenomic Era, or Why We Need 300,000 Mice Strains

... in the field of physiology and medicine awarded to Drs. Mario R. Capecchi (United States), Martin J. Evans, and Oliver Smithies (United Kingdom) for the their discovery of principles for introducing specific gene modifications in mice by the use of embryonic stem cells, i. e., for the gene knockout method applicable to individual genes. This method has demonstrated that a gene switch-off can influence not only the “target traits” controlled by this gene but also many other characteristics ...

Modified: 30.08.2008
genotype , genetically engineered mice , transgenic mice , knockout genes , knockout mice , gene expression , GFP , point mutations , genetic lines , embryo , cryobank , cryoarchive , SPF-animals , SPF-vivarium , Institute of Cytology and Genetics SB RAS
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The Postgenomic Era. Cryoarchiving by the Example of Mustelids

... problem of the drastic increase in the number of laboratory animal strains could be alleviated by cryobanking of these genetic resources. The Federation of International Mouse Resources (FIMRe) supplied with cryoarchive was established. Frozen semen and embryos are collected in these cryobanks, thus needed strain may be re-established by embryo transfer and (or) artifical insemination. The FIMRe unites the leading Animal Resource Centers of North America, Europe, Japan, and Australia. This article briefly ...

Modified: 30.08.2008
mustelids , ferrets , stoats , carnivores , reproductive technologies , cryobank , embryo freezing , embryo , cryopreservation , transplantation
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To the «Star Gate». From Conception to Birth

... incredible, great processes and mechanisms of realization for an organism newly arrived in this world have largely remained unclear until now, already available information allows making certain generalizations. Scientific and practical interest in embryonic and impetus periods in the realization of living creatures, including man, is explained not only by the fact that the problem of reproduction is important, urgent and eternal but also by the fact that it touches upon problems of natural science,...

Modified: 30.08.2008
pregnancy , abortion , prenatal period , embryo , fetus , perinatal medicine , demography
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