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The Postgenomic Era, or Why We Need 300,000 Mice Strains

... As for the “genetic” text, the situation is even more complicated because the process of “reading” this information comprises several stages, with possible correction and recoding at each stage. Eventually, an elementary event at the level of genotype, starting from the transcription of a particular gene, acquires a significant ambiguity at the level of phenotype. Application fields for genetic animal models:  (1) Models of diseases. (2) Functional genomic. (3) Preclinical studies To ...

Modified: 30.08.2008
genotype , genetically engineered mice , transgenic mice , knockout genes , knockout mice , gene expression , GFP , point mutations , genetic lines , embryo , cryobank , cryoarchive , SPF-animals , SPF-vivarium , Institute of Cytology and Genetics SB RAS
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