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The Postgenomic Era, or Why We Need 300,000 Mice Strains

... only the “target traits” controlled by this gene but also many other characteristics of the organism as a whole. This is the so called pleiotropic action of genes, well-known to geneticists. However, the pleiotropy scale observed when studying knockout genes is beyond all bounds. Note that our contemporaries in this case frequently find themselves in the situation analogous to that of Aristotle and the brain. However, unlike the ancient scientists, they quickly find the way out by following ...

Modified: 30.08.2008
genotype , genetically engineered mice , transgenic mice , knockout genes , knockout mice , gene expression , GFP , point mutations , genetic lines , embryo , cryobank , cryoarchive , SPF-animals , SPF-vivarium , Institute of Cytology and Genetics SB RAS
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