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The Postgenomic Era, or Why We Need 300,000 Mice Strains

... Biblical week; however, the situation had a most matter-of-fact resolution. “Three essences” of a genetically modified mouse: (1) Research object. (2) Research tool. (3) Component of biotechnological production The weekly rhythm observed in knockout mice mainly manifested itself as mass mortality on Mondays and Thursdays. It appeared that according to the cleaning schedule, vacuum-cleaners were used in vivarium on these days, and their noise caused epileptic seizures in animals. A special ...

Modified: 30.08.2008
genotype , genetically engineered mice , transgenic mice , knockout genes , knockout mice , gene expression , GFP , point mutations , genetic lines , embryo , cryobank , cryoarchive , SPF-animals , SPF-vivarium , Institute of Cytology and Genetics SB RAS
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The Postgenomic Era. Genetic Knockout

... favorite genetic object. Scientists involved in studying the main behavior regulator, the brain, have found revolutionary opportunities connected with the astounding success in decoding the gene structure and elaborating methods for creating transgenic and knockout mice. The strategy for genetic knockout provides for obtaining mouse strains with an irreversible damage of a particular gene and, correspondingly, the absence of the specific protein—the receptor for mediator or an enzyme involved in its ...

Modified: 30.08.2008
genetic knockout , transgenic mice , knockout mice , MAO-A , genome , behavior , mediators
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