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New Nucleic Acid Analogs: A Potential “Medicine for Genes”

... oligonucleotide is sufficient to delay its cleavage in the cell for over an hour, whereas cell enzymes completely destroy a common oligonucleotide in less than five minutes. However, the point is that despite a considerable size of these supplements, phosphoryl guanidine oligonucleotides form complementary complexes with the target DNA that do not differ in their stability from the natural double-stranded helix. These new compounds are readily soluble in water; moreover, their electric neutrality theoretically enhances their penetration through a negatively charged surface of the ...

Modified: 04.09.2015
DNA , phosphoryl guanidine , nucleic acids , oligonucleotides
Path: Главная / News
Phosphoryl Guanidines: New Chemical Analogues of Nucleic Acids

... Novosibirsk chemists have synthesized a new class of nucleic acid analogues, namely, phosphoryl guanidines (Kupryushkin, Pyshnyi, and Stetsenko, 2014). When an unloaded rifle fires a shot What is similar and what is different between common nucleic acids and phosphoryl guanidines? A natural DNA or RNA molecule contains negatively charged phosphate groups (>PO2–), which connect adjacent nucleotides into a polynucleotide chain. As for the DNA analogues that have been obtained for the first time at the ICBFM SB RAS, those substitute uncharged ...

Modified: 30.08.2015
DNA , oligonucleotide analogs , phosphoryl guanidine
Path: Главная / Articles

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