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The Postgenomic Era, or Why We Need 300,000 Mice Strains

... collections of mouse embryonic stem cells with various knockout genes are currently developed in Europe, Canada, and Japan. In other words, an actual mouse “deluge” in the nearest future is quite real. In addition to the transgenic technology, point mutations are an important source for genetic diversity of model animals. They are induced by exposing animals to N-ethylnitrosourea (ENU): this chemical mutagen causes single substitutions of nucleotide bases, which can significantly influence ...

Modified: 30.08.2008
genotype , genetically engineered mice , transgenic mice , knockout genes , knockout mice , gene expression , GFP , point mutations , genetic lines , embryo , cryobank , cryoarchive , SPF-animals , SPF-vivarium , Institute of Cytology and Genetics SB RAS
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