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  • Language: Русская версия
Rubric: News of Science
Section: Medicine

Vaccination with Scent

Scientists from Novosibirsk institutes with the Siberian Branch of the Russian Academy of Sciences attempted to determine the influence of female scent signals on the male resistance to influenza infection in the experiments with laboratory animals

Last winter many of us failed to evade ILI — the acronym physicians use for influenza and influenza-like illnesses, which are plenteous during the cold season. As is known, there is no efficient therapy for influenza as well as for other viral infections. We can rely only on our own immunity be it innate or acquired, which is a pool of specific protective antibodies generated as a result of a former disease or vaccination.

Logical considerations suggest that the “strength” of the nonspecific immunity in our body, i. e., the resistance to any external infectious agents, can be determined by several factors of various natures. However, it is difficult to assess experimentally the effects of these factors on humans, to say nothing of the ethical aspect of this approach, as the organism of any person is a unique “product” of a long-term individual life process. How much better are laboratory mice, especially those of the so-called pure strains: all possible parameters used for characterizing these rodents are unified!

Scientists from institutes with the Siberian Branch of the Russian Academy of Sciences — the Institute of Animal Systematics and Ecology and the Institute of Chemical Biology and Fundamental Medicine — have conducted an unusual experiment to clarify how the scent signals carrying the information about reproduction, perhaps, the most significant process from the evolutionary standpoint, influence immunity. Four groups of male mice of the BALB/c strain were infected with influenza virus. Some of them were vaccinated beforehand with a standard influenza vaccine, whereas the others were exposed to female scent for one month. One of these groups was a control: the mice were not inoculated and were isolated from females for 7 days.

Scientists from the Institute of Animal Systematics and Ecology have already discovered that the chemosignals from females inhibit the specific humoral immune response in males. This is explainable: when high-spending...

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